This case study takes a combined directed and discussion approach to explore …
This case study takes a combined directed and discussion approach to explore risk factors for breast cancer. After a preparatory reading assignment, students assess various medical histories derived from actual women with breast cancer and rank their overall risk for breast cancer and make recommendations for risk reduction. The task is complicated by the different and often combined sources of risk (e.g., reproductive history, hormone replacement therapy and family history). Originally written for an introductory biology course, the case study could easily be adapted for upper division curses in genetics, physiology, or biochemistry to explore the biological and biochemical basis underlying various risk factors.
Students are introduced to the respiratory system, the lungs and air. They …
Students are introduced to the respiratory system, the lungs and air. They learn about how the lungs and diaphragm work, how air pollution affects lungs and respiratory functions, some widespread respiratory problems, and how engineers help us stay healthy by designing machines and medicines that support respiratory health and function.
The trachea bifurcates at the levels of the 4th-6th intercostal space, approximately …
The trachea bifurcates at the levels of the 4th-6th intercostal space, approximately halfway between the thoracic inlet and the diaphragm. It divides into two principle bronchi, tubes which conduct air into the lungs, and they divide into two lobar bronchi for the left lung, and into four lobar bronchi for the right lung. These further divide into smaller bronchi and bronchioles within the lung tissue.
The Bursa of Fabricus is a primary lymphoid organ found in birds. …
The Bursa of Fabricus is a primary lymphoid organ found in birds. The bursa was the first place that a certain subset of lymphocytes was observed and consequently they were named B lymphocytes (bursa of Fabricius or bursa equivalent organs). The bursa is involved in the differentiation of B lymphocytes.
Development of the Central Nervous System (CNS) includes development of the brain, …
Development of the Central Nervous System (CNS) includes development of the brain, spinal cord, optic and auditory systems, as well as surrounding supporting cells including ependymal cells, astrocytes, oligodendrocytes and microglia. Information within this page will exclude development of the Peripheral Nervous System (PNS) which includes nerve and ganglia formation.
Blood is supplied to the brain from a ventral arterial supply in …
Blood is supplied to the brain from a ventral arterial supply in all species; from a circle of arteries called the Circle of Willis (also called the cerebral arterial circle or arterial circle of Willis) which lies ventrally to the hypothalamus where it forms a loose ring around the infundibular stalk. Although the appearance of the circle of Willis is fairly constant amongst mammals, the sources of blood supply to the circle and the direction of flow around the circle are very species specific. Blood is supplied to the brain by the internal carotid artery in dogs and horses whilst in other domestic species the main blood supply is from branches of the maxillary artery.
The cecum is a blind ending diverticulum of the large intestine and …
The cecum is a blind ending diverticulum of the large intestine and it exists at the junction of the ileum and the ascending colon. Its size and physiological importance varies between species. It is a site of microbial fermentation, absorption and transportation.
Camelids have a similar digestive structure to other ruminants, although camelids only …
Camelids have a similar digestive structure to other ruminants, although camelids only have three separate stomach compartments compared to the four found in domestic species. The first element of the camelid GI tract, known as C1, can be compared to the rumen whilst the second, known as C2 can be compared to the reticulum. The final element of the tract, C3 can be compared to the abomasum. Therefore camelids do not have a structure comparable to an omasum.
Since caffeine is a widely used substance, especially by college age students, …
Since caffeine is a widely used substance, especially by college age students, this case on the effects of caffeine on the human body serves as a real-world connection to many students' lives. The case is divided into sections covering background information on caffeine, cell biology and signal transduction, Parkinson's disease, cardiovascular effects, and addiction/withdrawal. The case was designed so that a section can be used alone or in combination with other sections, as dictated by topic/curriculum needs. It would be appropriate for use in a variety of science and health related courses, including anatomy and physiology, disease related courses, genetics, cell biology, molecular biology, biochemistry, and neuroscience.
After completing the associated lesson and its first associated activity, students are …
After completing the associated lesson and its first associated activity, students are familiar with the 20 major bones in the human body knowing their locations and relative densities. When those bones break, lose their densities or are destroyed, we look to biomedical engineers to provide replacements. In this activity, student pairs are challenged to choose materials and create prototypes that could replace specific bones. They follow the steps of the engineering design process, researching, brainstorming, prototyping and testing to find bone replacement solutions. Specifically, they focus on identifying substances that when combined into a creative design might provide the same density (and thus strength and support) as their natural counterparts. After iterations to improve their designs, they present their bone alternative solutions to the rest of the class. They refer to the measured and calculated densities for fabricated human bones calculated in the previous activity, and conduct Internet research to learn the densities of given fabrication materials (or measure/calculate those densities if not found online).
Michelle Gallagher, Terri Camesano, Jeanne Hubelbank, Kristen Billiar
Inquiry-Based Bioengineering Research and Design Experiences for Middle-School Teachers RET Program, Department of Biomedical Engineering, Worcester Polytechnic Institute,
In this discussion case, parents must decide whether or not to enroll …
In this discussion case, parents must decide whether or not to enroll their sons in an experimental treatment program designed to alleviate the symptoms of muscular dystrophy. The case explores the genetics and physiology of the disease as well as the issues involved with pharmaceutical research. The case has been used in both majors' and non-majors' biology courses, where it is introduced during a unit on the cardiovascular and muscular systems.
This case study is designed to teach students at various levels about …
This case study is designed to teach students at various levels about large biomolecules, nutrition, and product analysis. Students conduct a biochemical analysis of several popular energy drinks on the market, which many students purchase at fairly high prices, and determine whether these products nutritionally match their marketing claims. The case can be used as a review of basic biochemistry and nutrition for upper level students in physiology, biochemistry, or nutrition courses, or to introduce this information in introductory level courses in these disciplines.
The mammalian cardiovascular and respiratory systems have evolved primarily to provide the …
The mammalian cardiovascular and respiratory systems have evolved primarily to provide the tissues of the body with oxygen and to remove carbon dioxide. The cardiorespiratory system also has metabolic and heat exchange roles.
Each mammary complex consists of 5-20 mammary units and their corresponding ducts. …
Each mammary complex consists of 5-20 mammary units and their corresponding ducts. The ducts open separately on the tip of the teat. Shallow grooves indicate the border between complexes. An intermammary sulcus divides the right from the left row.
"Samuel Dexter" is 52 years old, overweight, and a heavy smoker. He …
"Samuel Dexter" is 52 years old, overweight, and a heavy smoker. He wakes one morning with weakness on his right side. When he attempts to walk to the bathroom, he stumbles and then falls. His wife, who suspects he has suffered a stroke, calls 911. Students read the short case scenario, including a brief clinical history of the patient and description of his injury, then answer a set of directed questions designed to probe the students' knowledge of the anatomy, physiology, and pathology underlying the patient's condition. The case has been used in both a sophomore-level course in human anatomy and physiology and a senior-level course in general physiology.
"Amanda Richards," a 20-year-old junior in college, is majoring in biology and …
"Amanda Richards," a 20-year-old junior in college, is majoring in biology and hopes to be a pediatrician one day. For about a month, she has been waking up frequently at night to go to the bathroom. Most recently, she has noticed that she needs to go to the bathroom during the day more often, almost houlyr. Students read about these symptoms and then answer a set of directed questions designed to teach facts and principles of physiology using reference books, textbooks, the Internet, and each other as sources of information. The case has been used in a sophomore-level course in human anatomy and physiology as well as in senior-level course in general physiology.
"Dolores Welborn," a 28-year-old attorney, is pregnant with her first child. Lately …
"Dolores Welborn," a 28-year-old attorney, is pregnant with her first child. Lately she has been tiring easily and is often short of breath. She has also had periods of light-headedness, cramping in her legs, and a sore tongue. Students read a brief clinical history and a description of signs and symptoms, then answer a set of directed questions designed to probe the underlying anatomy, physiology, and pathology of the Dolores's condition. In the process, they learn about the human hemolymphatic system. The case has been used in a sophomore-level course in human anatomy and physiology taught to pre-med and nursing students as well as in senior-level elective course in general physiology taken primarily by pre-med students.
"Allison Jacobson" is a 19-year-old sophomore majoring in pre-med. The past few …
"Allison Jacobson" is a 19-year-old sophomore majoring in pre-med. The past few weeks she has been studying for finals. She feels tired, even though she knows she has been getting enough sleep at night. She also has frequent headaches, and several times it has felt like her heart "missed a beat." Yesterday at lunch she fainted while waiting in line at the cafeteria. Students read a short description of the patient's history and symptoms, then answer a set of directed questions designed to probe their understanding of the anatomy, physiology, and pathology underlying the Allison's condition. The case has been used in both a sophomore-level course in human anatomy and physiology and a senior-level course in general physiology.
This clinical case study was developed to engage students by making connections …
This clinical case study was developed to engage students by making connections between core concepts in chemistry and physiological processes in the body. The case pertains to medication-induced methemoglobinemia, its etiology, diagnosis, and treatments. Concepts taught by the case include the use of conversion factors, pH, buffering, Le Chatelier's principle, blood chemistry, and respiratory and metabolic acidosis and alkalosis. The case is suitable for use in a General, Organic, and Biological (GOB) Chemistry course or other introductory general chemistry course as well as undergraduate physiology courses. The case also could be adapted for use in undergraduate pharmacology and medicinal chemistry courses.
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