Through this unit, students act as engineers who are given the challenge to design laparoscopic surgical tools. After learning about human anatomy and physiology of the abdominopelvic cavity, especially as it applies to laparoscopic surgery, students learn about the mechanics of elastic solids, which is the most basic level of material behavior. Then, they explore the world of fluids and learn how fluids react to forces. Next, they combine their understanding of the mechanics of solids and fluids to understand viscoelastic materials, such as those found in the human body. Finally, they learn about tissue mechanics, including how collagen, elastin and proteoglycans give body tissues their unique characteristics. In the culminating hands-on activity, student teams design their own prototypes of laparoscopic surgical robots remotely controlled, camera-toting devices that must fit through small incisions, inspect organs and tissue for disease, obtain biopsies, and monitor via ongoing wireless image-taking. They use a (homemade) synthetic abdominal cavity simulator to test and iterate the prototype devices.

Acting as biomedical engineers, students design, build, test and redesign prototype heart valves using materials such as waterproof tape, plastic tubing, flexible plastic and foam sheets, clay, wire and pipe cleaners. They test them with flowing water, representing blood moving through the heart. As students creatively practice engineering problem solving, they demonstrate their understanding of how one-way heart valves work.

This lesson covers the topic of human bones and joints. Students learn about the skeleton, the number of and types of bones in the body, and how outer space affects astronauts' bones. Students also learn how to take care of their bones here on Earth to prevent osteoporosis or weakening of the bones.

Vision is the primary sense of many animals and much is known about how vision is processed in the mammalian nervous system. One distinct property of the primary visual cortex is a highly organized pattern of sensitivity to location and orientation of objects in the visual field. But how did we learn this? An important tool is the ability to design experiments to map out the structure and response of a system such as vision. In this activity, students learn about the visual system and then conduct a model experiment to map the visual field response of a Panoptes robot. (In Greek mythology, Argus Panoptes was the "all-seeing" watchman giant with 100 eyes.) A simple activity modification enables a true black box experiment, in which students do not directly observe how the visual system is configured, and must match the input to the output in order to reconstruct the unseen system inside the box.

Through this lesson and its associated activity, students explore the role of biomedical engineers working for pharmaceutical companies. First, students gain background knowledge about what biomedical engineers do, how to become a biomedical engineer, and the steps of the engineering design process. The goal is to introduce biomedical engineering as medical problem solving as well as highlight the importance of maintaining normal body chemistry. Students participate in the research phase of the design process as it relates to improving the design of a new prescription medication. During the research phase, engineers learn about topics by reading scholarly articles written by others, and students experience this process. Students draw on their research findings to participate in discussion and draw conclusions about the impact of medications on the human body.

In a class demonstration, the teacher places different pill types ("chalk" pill, gel pill, and gel tablet) into separate glass beakers of vinegar, representing human stomach acid. After 20-30 minutes, the pills dissolve. Students observe which dissolve the fastest, and discuss the remnants of the various pills. What they learn contributes to their ongoing objective to answer the challenge question presented in lesson 1 of this unit.

Students are introduced to prosthetics history, purpose and benefits, main components, main types, materials, control methods, modern examples including modern materials used to make replacement body parts and the engineering design considerations to develop prostheses. They learn how engineers and medical doctors work together to improve the lives of people with amputations and the challenges faced when designing new prostheses with functional and cosmetic criteria and constraints. A PowerPoint(TM) presentation and two worksheets are provided.

To gain a better understanding of the roles and functions of components of the human respiratory system and our need for clean air, students construct model lungs that include a diaphragm and chest cavity. They see how air moving in and out of the lungs coincides with diaphragm movement. Then student teams design and build a prototype face mask pollution filter. They use their model lungs to evaluate their prototypes to design requirements.

Students use balloons (a polymer) to explore preconditioning a viscoelastic material behavior that is important to understand when designing biomedical devices. They improve their understanding of preconditioning by measuring the force needed to stretch a balloon to the same displacement multiple times. Students gain experience in data collection and graph interpretation.

Student teams investigate biomedical engineering and the technology of prosthetics. Students create a model prosthetic lower leg using various materials. Each team demonstrate its prosthesis' strength and consider its pros and cons, giving insight into the characteristics and materials biomedical engineers consider in designing artificial limbs.

Students reinforce their knowledge of the different parts of the digestive system and explore the concept of simulation by developing a pill coating that can withstand the churning actions and acidic environment found in the stomach. Teams test the coating durability by using a clear soda to simulate stomach acid.

Students design and build prototypes for protective eyewear. They choose different activities or sports that require protective eyewear and design a device for that particular use. Students learn about the many ways in which the eyes can be damaged and how engineers incorporate different features and materials into eyewear designs to best protect the eyes.

This lesson contains background about the blood vascular system and the heart. Also, the different sizes of capillaries, veins, and arteries, and how they affect blood flow through the system. We will then proceed to talk about the heart's function in the blood vascular system. This will lead into a discussion of heart valves, how they work and what might cause them to fail. Then we will discuss prosthetic heart valves.

Students learn the relevant equations for refraction (index of refraction, Snell's law) and how to use them to predict the behavior of light waves in specified scenarios. After a brief review of the concept of refraction (as learned in the previous lesson), the equations along with their units and variable definitions, are introduced. Student groups work through a few example conceptual and mathematical problems and receive feedback on their work. Then students conduct the associated activity during which they practice using the equations in a problem set, examine data from a porous film like those used in biosensors, and apply the equations they learned to a hypothetical scenario involving biosensors.

Students are introduced to the physical concept of the colors of rainbows as light energy in the form of waves with distinct wavelengths, but in a different manner than traditional kaleidoscopes. Looking at different quantum dot solutions, they make observations and measurements, and graph their data. They come to understand how nanoparticles interact with absorbing photons to produce colors. They learn the dependence of particle size and color wavelength and learn about real-world applications for using these colorful liquids.

Students groups act as NASA/GM engineers challenged to design, build and test robotic hands, which are tactile feedback systems made from cloth gloves and force sensor circuits. Student groups construct force sensor circuits using electric components and FlexiForce sensors to which resistance changes based on the applied force. They conduct experiments to find the mathematical relationship between the force applied to the sensor and the output voltages of the circuit. They take several measurements force vs. resistance, force vs. voltage and use the data to find the best fit curve models for the sensor. Different weights applied to the sensor are used as a scalable force. Students use traditional methods and current technology (calculators) to plot the collected data and define the curve equations. Students test their gloves and use a line of best fit to determine the minimum force required to crack an egg held between the index finger and thumb. A PowerPoint(TM) file and many student handouts are included.

Students see and learn how crystallization and inhibition occur by making sugar crystals with and without additives in a supersaturation solution, testing to see how the additives may alter crystallization, such as by improving crystal growth by more or larger crystals. After three days, students analyze the differences between the control crystals and those grown with additives, researching and attempting to deduce why certain additives blocked crystallization, showed no change or improved growth. Students relate what they learn from the rock candy experimentation to engineering drug researchers who design medicines for targeted purposes in the human body. Conduct the first half of this activity one day before presenting the associated lesson, Body Full of Crystals. Then conduct the second half of the activity.

Students use their knowledge about how healthy heart valves function to design, construct and implant prototype replacement mitral valves for hypothetical patients' hearts. Building on what they learned in the associated lesson about artificial heart valves, combined with the testing and scoring of their prototype heart valve designs in this activity, students discover the pros and cons of different types of artificial heart valves based on materials, surgery requirements, and lifespan.

Through this concluding lesson and its associated activity, students experience one valuable and often overlooked skill of successful scientists and engineers communicating your work and ideas. They explore the importance of scientific communication, including the basic, essential elements of communicating new information to the public and pitfalls to avoid. In the associated activity, student groups create posters depicting their solutions to the unit's challenge question accurate, efficient methods for detecting cancer-causing genes using optical biosensors which includes providing a specific example with relevant equations. Students are also individually assessed on their understanding of refraction via a short quiz. This lesson and its associated activity conclude the unit and serve as the culminating Go Public phase of the Legacy Cycle, providing unit review and summative assessment.

Students are introduced to several types of common medical sensor devices, such as ear and forehead thermometers, glucometers and wrist blood pressure monitors; they use the latter to measure their blood pressure and pulse rates. Students also measure their heights and weights in order to calculate their BMIs (body mass index). Then they use the collected data to create and analyze scatterplots of the different variables to determine if any relationships exist between the measured variables. Discussions about the trends observed and possible health concerns conclude the activity.