In this activity, students examine how to grow plants the most efficiently. They imagine that they are designing a biofuels production facility and need to know how to efficiently grow plants to use in this facility. As a means of solving this design problem, they plan a scientific experiment in which they investigate how a given variable (of their choice) affects plant growth. They then make predictions about the outcomes and record their observations after two weeks regarding the condition of the plants' stem, leaves and roots. They use these observations to guide their solution to the engineering design problem. The biological processes of photosynthesis and transpiration are briefly explained to help students make informed decisions about planning and interpreting their investigation and its results.

This activity is a field investigation where students observe plants, animals, and insects that are common to Minnesota.

This activity is a field investigation of the biodiversity in a given area. The exercise will give students experience making scientific observations and creating a dichotomous key.

This activity is a field investigation where student gather data on organisms they find in or around a pond.

Cellular responses to DNA damage constitute one of the most important fields in cancer biology. In this class we will analyze classical and recent papers from the primary research literature to gain a profound understand of cell cycle regulation and DNA damage checkpoints that act as powerful emergency brakes to prevent cancer. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

This online interactive module of 10 pages or frames integrates textual information, 3D molecular models, interactive molecular simulations, and embedded assessment items to guide students in understanding the copying of DNA base sequences from translation to transcription into proteins within each cell. The module divides the exercises in to Day 1 and Day 2 time frames. Teachers can view student assessment responses by assigning the module within a class created within the Molecular Workbench application. This Java-based module must be downloaded to each computer. 

This three-act film tells the story of the detective work that solved the mystery of what caused the disappearance of the dinosaurs at the end of the Cretaceous period. Shot on location in Italy, Spain, Texas, Colorado, and North Dakota, the film traces the uncovering of key clues that led to the discovery that an asteroid struck the Earth 66 million years ago, triggering a mass extinction of animals, plants, and microorganisms. Science practices in geology, physics, biology, chemistry and paleontology all contributed to the solution to this compelling mystery. Lesson plans are included that have students identify evidence and construct an explanation to tie it together. Summary questions are included at the end and a class discussion is recommended. (This activity will be the only one evaluated in this review.) Another resource is “Finding the Crater” where students “visit” different K-T boundary sites. There are also lessons where students analyze various characteristics of the asteroid such as its size and energy, chemical data about the asteroid, and the iridium fallout from an asteroid impact. A hands-on activity where students study the differences in foraminifera fossils below and above the K-T boundary is also included as well as an article that outlines more details about each of the discoveries covered in the film. You can view the film on the website or HHMI will send you a free DVD. Lesson plans including teacher notes and a student handout can be found at http://www.hhmi.org/biointeractive/following-trail-evidence.

This is an integration of science leaf observations with musical composition for early elementary students.

This activity combines field exercise soil collection with lab analysis of soil bulk density. Students develop a lab procedure to measure density and analyze data using Microsoft Excel computer software.

In this course, the student will learn about the field of developmental biology from its origins to the present day. The course will take a look at historical experiments as well as modern techniques and the mechanisms of development. The student will follow a variety of metazoan organisms from their start at fertilization through the stages of their development and on to entire organismal and post-embryonic development, learning along the way about the molecular and genetic regulations involved in these processes. (Biology 310)

The principles involved in morphogenesis and the determination of complex cellular patterns are examined using examples from animal systems in which the tools of genetics, molecular biology and cell biology have been applied to reveal mechanism. This graduate and advanced undergraduate level lecture and literature discussion course covers the current understanding of the molecular mechanisms that regulate animal development. Evolutionary mechanisms are emphasized as well as the discussion of relevant diseases. Vertebrate (mouse, chick, frog, fish) and invertebrate (fly, worm) models are covered. Specific topics include formation of early body plan, cell type determination, organogenesis, morphogenesis, stem cells, cloning, and issues in human development.

Considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior.

How does a regenerating animal "know" what's missing? How are stem cells or differentiated cells used to create new tissues during regeneration? In this class we will take a comparative approach to explore this fascinating problem by critically examining classic and modern scientific literature about the developmental and molecular biology of regeneration. We will learn about conserved developmental pathways that are necessary for regeneration, and we will discuss the relevance of these findings for regenerative medicine. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

In this interactive demonstration students will make observations of diffusion of a semi permeable membrane and be able to compare these observations to the functions of a cell membrane.

In a multi-week experiment, student teams gather biogas data from the mini-anaerobic digesters that they build to break down different types of food waste with microbes. Using plastic soda bottles for the mini-anaerobic digesters and gas measurement devices, they compare methane gas production from decomposing hot dogs, diced vs. whole. They monitor and measure the gas production, then graph and analyze the collected data. Students learn how anaerobic digestion can be used to biorecycle waste (food, poop or yard waste) into valuable resources (nutrients, biogas, energy).

Enzymes, nature's catalysts, are remarkable biomolecules capable of extraordinary specificity and selectivity. Directed evolution has been used to produce enzymes with many unique properties, including altered substrate specificity, thermal stability, organic solvent resistance, and enantioselectivity--selectivity of one stereoisomer over another. The technique of directed evolution comprises two essential steps: mutagenesis of the gene encoding the enzyme to produce a library of variants, and selection of a particular variant based on its desirable catalytic properties. In this course we will examine what kinds of enzymes are worth evolving and the strategies used for library generation and enzyme selection. We will focus on those enzymes that are used in the synthesis of drugs and in biotechnological applications. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

In this video module, students learn how scientists use genetic information from dogs to find out which gene (out of all 20,000 dog genes) is associated with any specific trait or disease of interest. This method involves comparing hundreds of dogs with the trait to hundreds of dogs not displaying the trait, and examining which position on the dog DNA is correlated with the trait (i.e. has one DNA sequence in dogs with the trait but another DNA sequence in dogs not displaying the trait). Students will also learn something about the history of dog breeds and how this history helps us find genes.

Scientists who are working to discover new medicines often use robots to prepare samples of cells, allowing them to test chemicals to identify those that might be used to treat diseases. Students will meet a scientist who works to identify new medicines. She created free software that ''looks'' at images of cells and determines which images show cells that have responded to the potential medicines. Students will learn about how this technology is currently enabling research to identify new antibiotics to treat tuberculosis. Students will complete hands-on activities that demonstrate how new medicines can be discovered using robots and computer software, starring the student as ''the computer.'' In the process, the students learn about experimental design, including positive and negative controls.

In this unit, students make regular journal entries about a plant/animal/insect community in the natural area around our school and use this to create a Non-fiction Class Book. They also interview family/resources to discover, record and present stories about human relationships with nature from their culture(s).

This activity is a field investigation where students find out what makes up soil.