In this course we will explore the new emerging field of pathogen-induced chronic diseases. Work in this field has redefined the causes of some major disorders, such as ulcers. By reading the primary research literature we will learn about the molecular mechanisms through which pathogens cause disease. The diseases that we cover will be introduced with a short patient case study. We will discuss the bacterium Helicobacter pylori and gastric disease, HPV and cervical cancer, hepatitis C virus and liver disease, Epstein-Barr virus and lymphoma, Cytomegalovirus and atherosclerosis, as well as diabetes and multiple sclerosis. We will study technical advances in the fight against microbes and explore future directions for new treatment strategies of chronic infections and inflammation. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

In a multi-week experiment, students monitor the core temperatures of two compost piles, one control and one tended, to see how air and water affect microbial activity. They daily aerate and wet the "treated" pile and collect 4-6 weeks' worth of daily temperature readings. Once the experiment is concluded, students plot and analyze their data to compare the behavior of the two piles. They find that the treated pile becomes hotter, an indication that more microbes are active and releasing heat. Through this activity, students see that microbes play a role in composting and how composting can be used as a carbon management process.

In a multi-week experiment, student teams gather biogas data from the mini-anaerobic digesters that they build to break down different types of food waste with microbes. Using plastic soda bottles for the mini-anaerobic digesters and gas measurement devices, they compare methane gas production from decomposing hot dogs, diced vs. whole. They monitor and measure the gas production, then graph and analyze the collected data. Students learn how anaerobic digestion can be used to biorecycle waste (food, poop or yard waste) into valuable resources (nutrients, biogas, energy).

This field and classroom activity involves identification of similarities, differences, advantages, and disadvantages in survival, method of locomotion, food acquisition, and reproduction in three fresh-water microbes.

Jessica Green wants people to understand the important role microbes play in every facet of our lives: climate change, building ecosystems, human health, even roller derby — using nontraditional tools like art, animation and film to help people visualize the invisible world. Ecologist and TED Fellow Jessica Green has found that mechanical ventilation does get rid of many types of microbes, but the wrong kinds: the ones left in the hospital are much more likely to be pathogens. About the speakerJessica Green · Engineer and biodiversity scientist Jessica Green wants people to understand the important role microbes play in every facet of our lives: climate change, building ecosystems, human health, even roller derby — using nontraditional tools like art, animation and film to help people visualize the invisible world. Should we keep the outdoors out of hospitals?

In a class demonstration, students observe a simple water cycle model to better understand its role in pollutant transport. This activity shows one way in which pollution is affected by the water cycle; it simulates a point source of pollution in a lake and the resulting environmental consequences.

Bacteria survive in almost all environments on Earth, including some considered extremely harsh. From the steaming hot springs of Yellowstone to the frozen tundra of the arctic to the barren deserts of Chile, microbes have been found thriving. Their tenacity to survive in such extreme and varied conditions allows them to play fundamental roles in global nutrient cycling. Microbes also cause a wide range of human diseases and can survive inhospitable conditions found in the human body. In this course, we will examine the molecular systems that bacteria use to adapt to changes in their environment. We will consider stresses commonly encountered, such as starvation, oxidative stress and heat shock, and also discuss how the adaptive responses affect the evolution of the bacteria. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

This course explores the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.