Lectures, laboratory exercises, and projects in modern optics. Topics: polarization properties of light, reflection and refraction, coherence and interference, Fraunhofer and Fresnel diffraction, imaging and transforming properties of lenses, spatial filtering, coherent optical processors, holography, optical properties of materials, lasers, nonlinear optics, electro-optic and acousto-optic materials and devices, optical detectors, fiber optics, and optical communication.

Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature.

An introductory course in the molecular biology of the auditory system. First half focuses on human genetics and molecular biology, covering fundamentals of pedigree analysis, linkage analysis, molecular cloning, and gene analysis as well as ethical/legal issues, all in the context of an auditory disorder. Second half emphasizes molecular approaches to function and dysfunction of the cochlea, and is based on readings and discussion of research literature.

This course develops and applies scaling laws and the methods of continuum and statistical mechanics to biomechanical phenomena over a range of length scales, from molecular to cellular to tissue or organ level.

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

This courses focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations. This term, we focus on hepatocellular carcinoma (HCC), chronic-active hepatitis, and hepatitis virus infections. In addition to lectures, students work in teams to critically evaluate and present primary scientific papers.

Languages and compilers to exploit multithreaded parallelism. Implicit parallel programming using functional languages and their extensions. Higher-order functions, non-strictness, and polymorphism. Explicit parallel programming and nondeterminism. The lambda calculus and its variants. Term rewriting and operational semantics. Compiling multithreaded code for symmetric multiprocessors and clusters. Static analysis and compiler optimizations.

Computer-aided design methodologies for synthesis of multivariable feedback control systems. Performance and robustness trade-offs. Model-based compensators; Q-parameterization; ill-posed optimization problems; dynamic augmentation; linear-quadratic optimization of controllers; H-infinity controller design; Mu-synthesis; model and compensator simplification; nonlinear effects. Computer-aided (MATLAB) design homework using models of physical processes. This course uses computer-aided design methodologies for synthesis of multivariable feedback control systems. Topics covered include: performance and robustness trade-offs; model-based compensators; Q-parameterization; ill-posed optimization problems; dynamic augmentation; linear-quadratic optimization of controllers; H-infinity controller design; Mu-synthesis; model and compensator simplification; and nonlinear effects. The assignments for the course comprise of computer-aided (MATLABĺ¨) design problems.

Growth and development of normal bone and joints, the process of mineralization, the biophysics of bone and response to stress and fracture, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, and the pathogenesis of metabolic bone diseases and disease of connective tissue, joints, and muscles, with consideration of possible mechanisms and underlying metabolic derangements.

Watson and Crick noted that the size of a viral genome was insufficient to encode a protein large enough to encapsidate it and reasoned, therefore that a virus shell must be composed of multiple, but identical subunits. Today, high resolution structures of virus capsids reveal the basis of this genetic economy as a highly symmetrical structure, much like a geodesic dome composed of protein subunits. Crystallographic structures and cryo-electron microscopy reconstructions combined with molecular data are beginning to reveal how these nano-structures are built. Topics covered in the course will include basic principles of virus structure and symmetry, capsid assembly, strategies for enclosing nucleic acid, proteins involved in entry and exit, and the life cycles of well understood pathogens such as HIV, influenza, polio, and Herpes. A review of cutting edge structural methods is also covered.

This course focuses on the latest scientific developments and discoveries in the field of nanomechanics, the study of forces and motion on extremely tiny (10-9 m) areas of synthetic and biological materials and structures. At this level, mechanical properties are intimately related to chemistry, physics, and quantum mechanics. Most lectures will consist of a theoretical component that will then be compared to recent experimental data (case studies) in the literature. The course begins with a series of introductory lectures that describes the normal and lateral forces acting at the atomic scale. The following discussions include experimental techniques in high resolution force spectroscopy, atomistic aspects of adhesion, nanoindentation, molecular details of fracture, chemical force microscopy, elasticity of single macromolecular chains, intermolecular interactions in polymers, dynamic force spectroscopy, biomolecular bond strength measurements, and molecular motors.

Parallel treatments of photons, electrons, phonons, and molecules as energy carriers, aiming at fundamental understanding and descriptive tools for energy and heat transport processes from nanoscale continuously to macroscale. Topics include the energy levels, the statistical behavior and internal energy, energy transport in the forms of waves and particles, scattering and heat generation processes, Boltzmann equation and derivation of classical laws, deviation from classical laws at nanoscale and their appropriate descriptions, with applications in nano- and microtechnology.

Relationship between computer representation of knowledge and the structure of natural language. Emphasizes development of the analytical skills necessary to judge the computational implications of grammatical formalisms, and uses concrete examples to illustrate particular computational issues. Efficient parsing algorithms for context-free grammars; augmented transition network grammars. Question answering systems. Extensive laboratory work on building natural language processing systems. 6.863 is a laboratory-oriented course on the theory and practice of building computer systems for human language processing, with an emphasis on the linguistic, cognitive, and engineering foundations for understanding their design.

Today, computer-based simulations are becoming increasingly popular, especially when daylighting and energy conservation are amongst the key goals for a project. This two-week workshop will expose participants to the current daylighting simulation models and beyond, by introducing realistic and dynamic assessment methods through hands-on exercises and application to a design project. Open to students and practitioners.

Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures.

Lectures and discussions explore the clinical, behavioral, and molecular aspects of brain aging processes in humans. Topics include: loss of memory and other cognitive abilitites in normal aging; neurodegenerative conditions such as Parkinson's and Alzheimer's diseases. Based on lectures, readings taken from the primary literature, and discussions. Students are expected to present topics based on their readings. One written mid-term test and one final examination. Alternate years.

The main goal of this seminar will be to study the nervous system from the perspective of neuron-glia interactions. In each class, we will focus on one type of glial cell and discuss its origin, classification and function within the nervous system. Current findings concerning diseases associated with each type of glial cell will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

" The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology. This course is offered during the Independent Activities Period (IAP), which is a special 4-week term at MIT that runs from the first week of January until the end of the month."

Principles of tomographic imaging using ionizing and non-ionizing radiation, and ultrasound. Emphasis is placed on fundamental physics and mathematics involved in image formation, including basic interactions, data acquisition and reconstruction. Planar radiographic imaging, multi-dimensional tomography (X-ray CAT, PET, SPECT), ultrasound, and NMR imaging covered. 22.56J aims to give graduate students and advanced undergraduates background in the theory and application of noninvasive imaging methods to biology and medicine, with emphasis on neuroimaging. The course focuses on the modalities most frequently used in scientific research (X-ray CT, PET/SPECT, MRI, and optical imaging), and includes discussion of molecular imaging approaches used in conjunction with these scanning methods. Lectures by the professor will be supplemented by in-class discussions of problems in research, and hands-on demonstrations of imaging systems.

Introduction to the theory and phenomenology of nonlinear dynamics and chaos in dissipative systems. Forced and parametric oscillators. Phase space. Periodic, quasiperiodic, and aperiodic flows. Sensitivity to initial conditions and strange attractors. Lorenz attractor. Period doubling, intermittency, and quasiperiodicity. Scaling and universality. Analysis of experimental data: Fourier transforms, Poincar, sections, fractal dimension, and Lyapunov exponents. Applications drawn from fluid dynamics, physics, geophysics, and chemistry.