In this course, we will discuss the microbial physiology and genetics of stress responses in aquatic ecosystems, astrobiology, bacterial pathogenesis and other environments. We will learn about classical and novel methods utilized by researchers to uncover bacterial mechanisms induced under both general and environment-specific stresses. Finally, we will compare and contrast models for bacterial stress responses to gain an understanding of distinct mechanisms of survival and of why there are differences among bacterial genera.

This workshop explores how designers might become as sensitive to space as they are to objects. Through a number of projects and precedent studies, architectural design is studied in relation to the Space Between. The design process is studied in reverse, considering space first and objects second. This is not to imply that objects are not important, but rather that space is equally important.

Fundamentals of human performance, physiology, and life support impacting engineering design and aerospace systems. Topics include: effects of gravity on the muscle, skeletal, cardiovascular, and neurovestibular systems; human/pilot modeling and human/machine design; flight experiment design; and life support engineering for extravehicular activity (EVA). Case studies of current research are presented. Assignments include a design project, quantitative homework sets, and quizzes emphasizing engineering and systems aspects.

The seminar explores current issues in space policy as well as the historical roots for the issues. Emphasis on critial policy discussion combined with serious technical analysis.The range of issues cover national security space policy, civil space policy, as well as commercial space policy. Issues explored include: the GPS dilemma, the International Space Station choices, commercial launch from foreign countries, and the fate of satellite-based cellular systems.

Reviews rocket propulsion fundamentals. Discusses advanced concepts in rocket propulsion ranging from chemical engines to electrical engines. Topics include: advanced mission analysis, physics and engineering of microthrusters, solid propellant rockets, electrothermal, electrostatic, and electro-magnetic schemes for accelerating propellant. Some coverage is given of satellite power systems and their relation to propulsion systems. Space Propulsion begins with a review of rocket propulsion fundamentals. The course then proceeds into advanced propulsion concepts, ranging from chemical to electrical engines. Propulsion system selection criteria and mission analysis are introduced. The bulk of the semester is devoted to the physics and engineering of various engine classes, including electrothermal, electrostatic and electro-magnetic. Specific topics include arcjets, ion engines, Hall thrusters and colloid thrusters.

Space System Architecture and Design incorporates lectures, readings and discussion on topics in the architecting of space systems. The class reviews existing space system architectures and the classical methods of designing them. Sessions focus on multi-attribute utility theory as a new design paradigm for space systems, when combined with integrated concurrent engineering and efficient searches of large architectural tradspaces. Designing for flexibility and uncertainty is considered, as are policy and product development issues.

In 16.89/ESD.352 the students will first be asked to understand the key challenges in designing ground and space telescopes, the stakeholder structure and value flows, and the particular pros and cons of the proposed project. The first half of the class will concentrate on performing a thorough architectural analysis of the key astrophysical, engineering, human, budgetary and broader policy issues that are involved in this decision. This will require the students to carry out a qualitative and quantitative conceptual study during the first half of the semester and recommend a small set of promising architectures for further study at the Preliminary Design Review (PDR).Both lunar surface telescopes as well as orbital locations should be considered. The second half of the class will then pick 1-2 of the top-rated architectures for a lunar telescope facility and develop the concept in more detail and present the detailed design at the Critical Design Review (CDR). This should not only sketch out the science program, telescope architecture and design, but also the stakeholder relationships, a rough estimate of budget and timeline, and also clarify the role that human explorers could or should play during both deployment and servicing/operations of such a facility (if any).

" This class focuses on representation tools used by architects during the design process and attempts to discuss the relationship they develop with the object of design. Representation plays a key role in architectural design, not only as a medium of conveying and narrating a determined meaning or a preconceived idea, but also as a code of creating new meaning, while the medium seeks to establish a relationship with itself. In this sense, mediums of representation, as external parameters to the design process, are not neutral tools of translating an idea into its concrete form. They are neither authentic means of creativity, nor vapid carriers of an idea. Therefore, an important aspect in issues of meaning is how the architect manipulates the play of translating a concept to its concrete version, through the use of a medium of representation. The course is a continuation of the equivalent course taught in the fall semester and specifically focuses on digital media. The course is intended to establish a reciprocal relationship with the design studio, feeding from and contributing to its content."

The course will investigate e-Learning systems from a business, policy, technical and legal perspective. The issues presented shall be tackled by discussion of the design and structure of the various example systems. The connection between information architectures and the physical workplace of the users will also be examined. There course will be comprised of readings, discussions, guest speakers and group design sessions. Laboratory sessions will be focused on implementation tools and opportunities to create one's own working prototypes. Students will learn to describe information architectures using the Unified Modeling Language (used to specify, design and structure web applications) and XML (to designate meaningful content).

" An opportunity for graduate study of advanced subjects in Brain and Cognitive Sciences not included in other subject listings. The key topics covered in this course are Bipolar Disorder, Psychosis, Schizophrenia, Genetics of Psychiatric Disorder, DISC1, Ca++ Signaling, Neurogenesis and Depression, Lithium and GSK3 Hypothesis, Behavioral Assays, CREB in Addiction and Depressive Behaviors, The GABA System-I, The GABA System-II, The Glutamate Hypothesis of Schizophrenia, The Dopamine Pathway and DARPP32."

Memory is not a unitary faculty, but rather consists of multiple forms of learning that differ in their operating characteristics and neurobiological substrates. This seminar will consider current debates regarding the cognitive and neural architectures of memory, specifically focusing on recent efforts to address these controversies through application of functional neuroimaging (primarily fMRI and PET).

" A great variety of processes affect the surface of the Earth. Topics to be covered are production and movement of surficial materials; soils and soil erosion; precipitation; streams and lakes; groundwater flow; glaciers and their deposits. The course combines aspects of geology, climatology, hydrology, and soil science to present a coherent introduction to the surface of the Earth, with emphasis on both fundamental concepts and practical applications, as a basis for understanding and intelligent management of the Earth's physical and chemical environment."

Introduction to a selection of mathematical topics that are not covered in traditional mechanical engineering curricula, such as differential geometry, integral geometry, discrete computational geometry, graph theory and optimization techniques. Emphasis on basic ideas and on applications in mechanical engineering. Selection will change every year. This course forms an introduction to a selection of mathematical topics that are not covered in traditional mechanical engineering curricula, such as differential geometry, integral geometry, discrete computational geometry, graph theory, optimization techniques, calculus of variations and linear algebra. The topics covered in any particular year depend on the interest of the students and instructor. Emphasis is on basic ideas and on applications in mechanical engineering. This year, the subject focuses on selected topics from linear algebra and the calculus of variations. It is aimed mainly (but not exclusively) at students aiming to study mechanics (solid mechanics, fluid mechanics, energy methods etc.), and the course introduces some of the mathematical tools used in these subjects. Applications are related primarily (but not exclusively) to the microstructures of crystalline solids.

This class is jointly sponsored by the MIT Museum, Massachusetts Bay Maritime Artisans, the Department of Mechanical Engineering's Center for Ocean Engineering, and the Department of Architecture. The course teaches the fundamental steps in traditional boat design and demonstrates connections between craft and modern methods. Instructors provide vessel design orientation and then students carve their own shape ideas in the form of a wooden half-hull model. Experts teach the traditional skills of visualizing and carving your model in this phase of the class. After the models are completed, a practicing naval architect guides students in translating shape from models into a lines plan. The final phase of the class is a comparative analysis of the designs generated by the group.

How do words get their meanings? How can word meanings be represented and used by machines? We will explore three families of approaches to these questions from a computational perspective. Relational / structural methods such as semantic networks represent the meaning of words in terms of their relations to other words. Knowledge of the world through perception and action leads to the notion of external grounding, a process by which word meanings are 'attached' to the world. How an agent theorizes about, and conceptualizes its world provides yet another foundation for word meanings. We will examine each of these perspectives, and consider ways to integrate them.

Subject presents a range of advanced topics in integrated logistics and supply chain management. Conducted in a lecture-discussion format, with participation of corporate executives as guest lecturers. Students prepare industry assessment analyses and make formal classroom presentations. Specific topics alternate from year to year, but basic content includes procurement strategies and strategic sourcing, dynamic pricing and revenue management tactics, mitigation of supply chain risk through supply contracts, strategic outsourcing of supply chain chain functions and operations, management and operation of third party logistics providers, and management of supply chain security.

An advanced seminar on issues of current interest in human and machine vision. Topics vary from year to year. Participants discuss current literature as well as their ongoing research.

Survey of structural properties of natural languages, with special emphasis on the sound pattern. Representation of the lexicon. Physiology of speech production, articulatory phonetics. Acoustical theory of speech production; acoustical and articulatory descriptions of phonetic features and of prosodic aspects of speech. Perception of speech. Models of lexical access and of speech production and planning. Applications to recognition and generation of speech by machine, and to the study of speech disorders.

This course focuses on the problem of supervised learning from the perspective of modern statistical learning theory starting with the theory of multivariate function approximation from sparse data. It develops basic tools such as Regularization including Support Vector Machines for regression and classification. It derives generalization bounds using both stability and VC theory. It also discusses topics such as boosting and feature selection and examines applications in several areas: Computer Vision, Computer Graphics, Text Classification and Bioinformatics. The final projects and hands-on applications and exercises are planned, paralleling the rapidly increasing practical uses of the techniques described in the subject.