Discusses social, ethical and clinical issues associated with the development of new biotechnologies and their integration into clinical practice. Basic scientists, clinicians, bioethicists, and social scientists present on four general topics: changing political economy of biotech research; problems associated with the adaption of new biotechnologies and findings from molecular biology for clinical settings; the ethical issues that emerge from clinical research and clinical use of new technologies; and the broader social ethics associated with investigations of population genetics and social problems. Use of cases and recent literature.

This course explores how social theories of urban life can be related to the city's architecture and spaces. It is grounded in classic or foundational writings about the city addressing such topics as the public realm and public space, impersonality, crowds and density, surveillance and civility, imprinting time on space, spatial justice, and the segregation of difference. The aim of the course is to generate new ideas about the city by connecting the social and the physical, using Boston as a visual laboratory. Students are required to present a term paper mediating what is read with what has been observed.

A reading and discussion subject on advanced topics in the engineering of software systems. Focus on software development. Topics differ but are chosen from: software process and lifecycle; requirements development, specification and analysis; design principles; testing, formal analysis, and reviews; quality management and assessment; product and process metrics; COTS and reuse; evolution and maintenance; team organization and people management; software engineering aspects of programming languages; and software psychology. Prerequisite is basic knowledge of programming and an introductory class in software engineering. The second prerequisite can be waived with permission of the instructor and additional background reading.

Computation over unreliable and anonymous protocols such as the World Wide Web. Problems of persistence, concurrency control, transactions, and transactions across multiple servers. The relational database management system as a tool for attacking these problems. Students work in small mentored teams on diverse projects. This is a course for students who already have some programming and software engineering experience. The goal is to give students some experience in dealing with those challenges that are unique to Internet applications, such as: concurrency; unpredictable load; security risks; opportunity for wide-area distributed computing; creating a reliable and stateful user experience on top of unreliable connections and stateless protocols; extreme requirements and absurd development schedules; requirements that change mid-way through a project, sometimes because of experience gained from testing with users; user demands for a multi-modal interface.

This is an introduction to the study of the solar system with emphasis on the latest spacecraft results. The subject covers basic principles rather than detailed mathematical and physical models. Topics include: an overview of the solar system, planetary orbits, rings, planetary formation, meteorites, asteroids, comets, planetary surfaces and cratering, planetary interiors, planetary atmospheres, and life in the solar system.

In this course, we will discuss the microbial physiology and genetics of stress responses in aquatic ecosystems, astrobiology, bacterial pathogenesis and other environments. We will learn about classical and novel methods utilized by researchers to uncover bacterial mechanisms induced under both general and environment-specific stresses. Finally, we will compare and contrast models for bacterial stress responses to gain an understanding of distinct mechanisms of survival and of why there are differences among bacterial genera.

This workshop explores how designers might become as sensitive to space as they are to objects. Through a number of projects and precedent studies, architectural design is studied in relation to the Space Between. The design process is studied in reverse, considering space first and objects second. This is not to imply that objects are not important, but rather that space is equally important.

Fundamentals of human performance, physiology, and life support impacting engineering design and aerospace systems. Topics include: effects of gravity on the muscle, skeletal, cardiovascular, and neurovestibular systems; human/pilot modeling and human/machine design; flight experiment design; and life support engineering for extravehicular activity (EVA). Case studies of current research are presented. Assignments include a design project, quantitative homework sets, and quizzes emphasizing engineering and systems aspects.

The seminar explores current issues in space policy as well as the historical roots for the issues. Emphasis on critial policy discussion combined with serious technical analysis.The range of issues cover national security space policy, civil space policy, as well as commercial space policy. Issues explored include: the GPS dilemma, the International Space Station choices, commercial launch from foreign countries, and the fate of satellite-based cellular systems.

Reviews rocket propulsion fundamentals. Discusses advanced concepts in rocket propulsion ranging from chemical engines to electrical engines. Topics include: advanced mission analysis, physics and engineering of microthrusters, solid propellant rockets, electrothermal, electrostatic, and electro-magnetic schemes for accelerating propellant. Some coverage is given of satellite power systems and their relation to propulsion systems. Space Propulsion begins with a review of rocket propulsion fundamentals. The course then proceeds into advanced propulsion concepts, ranging from chemical to electrical engines. Propulsion system selection criteria and mission analysis are introduced. The bulk of the semester is devoted to the physics and engineering of various engine classes, including electrothermal, electrostatic and electro-magnetic. Specific topics include arcjets, ion engines, Hall thrusters and colloid thrusters.

Space System Architecture and Design incorporates lectures, readings and discussion on topics in the architecting of space systems. The class reviews existing space system architectures and the classical methods of designing them. Sessions focus on multi-attribute utility theory as a new design paradigm for space systems, when combined with integrated concurrent engineering and efficient searches of large architectural tradspaces. Designing for flexibility and uncertainty is considered, as are policy and product development issues.

In 16.89/ESD.352 the students will first be asked to understand the key challenges in designing ground and space telescopes, the stakeholder structure and value flows, and the particular pros and cons of the proposed project. The first half of the class will concentrate on performing a thorough architectural analysis of the key astrophysical, engineering, human, budgetary and broader policy issues that are involved in this decision. This will require the students to carry out a qualitative and quantitative conceptual study during the first half of the semester and recommend a small set of promising architectures for further study at the Preliminary Design Review (PDR).Both lunar surface telescopes as well as orbital locations should be considered. The second half of the class will then pick 1-2 of the top-rated architectures for a lunar telescope facility and develop the concept in more detail and present the detailed design at the Critical Design Review (CDR). This should not only sketch out the science program, telescope architecture and design, but also the stakeholder relationships, a rough estimate of budget and timeline, and also clarify the role that human explorers could or should play during both deployment and servicing/operations of such a facility (if any).

" This class focuses on representation tools used by architects during the design process and attempts to discuss the relationship they develop with the object of design. Representation plays a key role in architectural design, not only as a medium of conveying and narrating a determined meaning or a preconceived idea, but also as a code of creating new meaning, while the medium seeks to establish a relationship with itself. In this sense, mediums of representation, as external parameters to the design process, are not neutral tools of translating an idea into its concrete form. They are neither authentic means of creativity, nor vapid carriers of an idea. Therefore, an important aspect in issues of meaning is how the architect manipulates the play of translating a concept to its concrete version, through the use of a medium of representation. The course is a continuation of the equivalent course taught in the fall semester and specifically focuses on digital media. The course is intended to establish a reciprocal relationship with the design studio, feeding from and contributing to its content."

The course will investigate e-Learning systems from a business, policy, technical and legal perspective. The issues presented shall be tackled by discussion of the design and structure of the various example systems. The connection between information architectures and the physical workplace of the users will also be examined. There course will be comprised of readings, discussions, guest speakers and group design sessions. Laboratory sessions will be focused on implementation tools and opportunities to create one's own working prototypes. Students will learn to describe information architectures using the Unified Modeling Language (used to specify, design and structure web applications) and XML (to designate meaningful content).

" An opportunity for graduate study of advanced subjects in Brain and Cognitive Sciences not included in other subject listings. The key topics covered in this course are Bipolar Disorder, Psychosis, Schizophrenia, Genetics of Psychiatric Disorder, DISC1, Ca++ Signaling, Neurogenesis and Depression, Lithium and GSK3 Hypothesis, Behavioral Assays, CREB in Addiction and Depressive Behaviors, The GABA System-I, The GABA System-II, The Glutamate Hypothesis of Schizophrenia, The Dopamine Pathway and DARPP32."

Memory is not a unitary faculty, but rather consists of multiple forms of learning that differ in their operating characteristics and neurobiological substrates. This seminar will consider current debates regarding the cognitive and neural architectures of memory, specifically focusing on recent efforts to address these controversies through application of functional neuroimaging (primarily fMRI and PET).

" A great variety of processes affect the surface of the Earth. Topics to be covered are production and movement of surficial materials; soils and soil erosion; precipitation; streams and lakes; groundwater flow; glaciers and their deposits. The course combines aspects of geology, climatology, hydrology, and soil science to present a coherent introduction to the surface of the Earth, with emphasis on both fundamental concepts and practical applications, as a basis for understanding and intelligent management of the Earth's physical and chemical environment."

Introduction to a selection of mathematical topics that are not covered in traditional mechanical engineering curricula, such as differential geometry, integral geometry, discrete computational geometry, graph theory and optimization techniques. Emphasis on basic ideas and on applications in mechanical engineering. Selection will change every year. This course forms an introduction to a selection of mathematical topics that are not covered in traditional mechanical engineering curricula, such as differential geometry, integral geometry, discrete computational geometry, graph theory, optimization techniques, calculus of variations and linear algebra. The topics covered in any particular year depend on the interest of the students and instructor. Emphasis is on basic ideas and on applications in mechanical engineering. This year, the subject focuses on selected topics from linear algebra and the calculus of variations. It is aimed mainly (but not exclusively) at students aiming to study mechanics (solid mechanics, fluid mechanics, energy methods etc.), and the course introduces some of the mathematical tools used in these subjects. Applications are related primarily (but not exclusively) to the microstructures of crystalline solids.

This class is jointly sponsored by the MIT Museum, Massachusetts Bay Maritime Artisans, the Department of Mechanical Engineering's Center for Ocean Engineering, and the Department of Architecture. The course teaches the fundamental steps in traditional boat design and demonstrates connections between craft and modern methods. Instructors provide vessel design orientation and then students carve their own shape ideas in the form of a wooden half-hull model. Experts teach the traditional skills of visualizing and carving your model in this phase of the class. After the models are completed, a practicing naval architect guides students in translating shape from models into a lines plan. The final phase of the class is a comparative analysis of the designs generated by the group.